Jonathan Thomas Elliott, PhD

I'm a Research Associate and Lecturer of Engineering Sciences at Dartmouth College in New Hampshire. I work in the Optics in Medicine Group as a CIHR Fellow in Cancer Research. My research strives to apply biotechnology--including imaging and sensing--to improve cancer surgery. Right now, I work mostly in the fluorescence-guided surgery space, where I develop smart probes that target tumors based on molecular expression.

I am also passionate about human-centered design: how can I provide high-level information to surgeons during complicated cancer surgery, in a way that is helpful and natural. This problem intersects medical imaging, tracer kinetics, computer vision, optical engineering, physiology, oncology, molecular biology, to name a few...which is perfect, since I love to learn new things every day!

Finally, I am also exploring novel imaging and therapeutic interventions for cancer patients in the developing world through low-cost optical imaging, wide-field automated pathology, and photodynamic therapy. My research goals, passion for teaching, and philanthropic desires converge on this single objective -- to use biomedical engineering to improve health care in some of the worlds poorest regions.

My teaching focus is on biomedical engineering for global health. I have developed, and instruct, an undergraduate survey-level course which challenges students to develop and apply skills in biomedical engineering to solve health challenges for low- and middle-income countries. I am passionate about improving the access and quality of healthcare for everyone, through research, teaching, and raising awareness.

When I'm not playing around with lasers, I am almost certainly hiking, skiing, or kicking around a ball with kids. I am fortunate to have the support of my wonderful wife Laura, the "high-fives" of our son, Yianni, and smiles of our daughter, Ruby, which encourage me each day. Thanks for visiting my website, where you'll find some information on my current projects. Feel free to contact me if you have any questions!

Be well,
Jonathan

Curriculum Vitae

Ph.D., Medical Biophysics, University of Western Ontario (2013)
Thesis Committee: Keith St. Lawrence (advisor), Ting-Yim Lee, Vladislav Toronov
" On the development of a dynamic contrast-enhanced near-infrared technique to measure cerebral blood flow in the neurocritical care unit”

B.M.Sc., (Honours) Medical Science, University of Western Ontario (2008)
Double Major in Physiology and Medical Biophysics

Awards

2013-2015  Canadian Institutes of Health Research Postdoctoral Fellowship

2012  Alfred Jay Award for Innovation and Entrepreneurship
2010-2011  SPIE Scholarship in Optical Science and Engineering
2012  Optical Society of America 2nd Prize

2011-2013  Ontario Graduate Scholarship
2010-2011  Ontario Graduate Scholarship in Science and Technology
2008-2013  Western Graduate Research Scholarship

Teaching and Mentoring

2014-2015 Lecturer of Engineering Science (ENGS 16, ENGG 166)
2015 Faculty Advisor, Dartmouth Team in Emory Global Health Case Competition

Invited Presentations

Shining a light on the brain (Retiring with Strong Minds – Outreach Project, Western University, London, ON; June 7, 2013)

Using CFD modeling to predict flow disturbance and thrombosis (Department of Otolaryngology, Western University, London, ON; May 9, 2012)

Monte Carlo Simulations: A random walk from blood flow measurements to fluorescence molecular tomography (Thayer School of Engineering, Dartmouth College, Hanover, NH; Dec. 2, 2011)

Introduction to Monte Carlo in optics – Lecture for MBP 9645a (Department of Medical Biophysics, Western University, London, ON; Nov. 14, 2011)

Features in Popular Press

Simple oximeter enables tracer kinetics in MedicalPhysicsWeb (Jan. 14, 2013)

 

Almost 1 in 4 people will get cancer in their lifetime. When that happens, it is hoped that chemotherapy, radiation and surgery will contribute to a postivie patient outcome. I work with surgeons and other researchers to help improve the outcomes of three significant types of cancer: brain cancer, pancreatic cancer and breast cancer.

Glioma surgery is challenging because the tumor invades into the normal brain, making it difficult to know which tissue to remove. I research and design image-guided surgical tools and analytics to improve the visualization and resection of tumor during open craniotomy. I have the privlege of working with a team of world-class Dartmouth researchers who are involved in several NIH funded projects including a grant to develop a safe antibody fragment based imaging agent and a grant that enabled the construction of a intraoperative CT and MRI suite.

My research is unique in that I exploit tracer kinetic methods from PET imaging, mainly arterial input based methods, to quantify binding and kinetic parameters. These provide a direct assessment of the molecular composition and physiological status of cancer tissue. Currently I am developing the appropriate arterial input models and means by which these can be evaluated [1].

I'm also part of a research team looking at using targeted photosensitizing agents to improve photodynamic therapy for unresectable pancreatic cancer and oral cancer. Our most recent work is in understanding how contrast enhanced CT can be used to guide PDT has been published.

Finally, a third area of focus is in wide field scatter-based imaging as a way of evaluating the ultrastructure of tissue in a macroscopic scale. Currently, about 35% of patients undergoing breast conserving therapy must return to the hospital for a second surgery because some tumor was left int he patient. This is because many tumors are being discovered early and are difficult to palpate (so the surgeon is cutting blind) and the histopathology cannot be performed intraoperatively due to problems with frozen section analysis of breast tissue. We have developed a rapid wide-field technique that provides contrast on the basis of scattering properties of tissue -- properties that are modified by cancer cells as they reorganize the extracellular matrix in order to expand. [3]

[1] Elliott JT et al. (2014) Direct characterization of arterial input functions by fluorescence imaging of exposed carotid artery to facilitate kinetic analysis. Molecular Imaging in Biology.

[2] Elliott JT et al. (2014) Perfusion CT estimates PS uptake and biodistribution in a rabbit orthotopic pancreatic cancer model: a pilot study Acad Radiol DOI: 10.1016/j.acra.2014.12.014

[3] Krishnaswamy V, Elliott JT, et al. (2014) Structured Light Scatteroscopy. J Biomed Opt 7(19): 070504.

I am a Lecturer of Engineering Sciences at Thayer School, coordinating and instructing undergraduate students in biomedical engineering for global health (ENGS16). This new course is a comprehensive, survey-level course designed to equip students with the skills necessary to develop global health technology for low- and middle-income countries. My teaching approach to this course strives to make the experience:

Experiential...

Engineering forms the bridge between scientific discovery and human experience—it is by its very nature, concerned with applying the scientific process to fill a human need. Global health encapsulates the breadth of human joy (the birth of a child) and human suffering from illness and death. My goal in ENGS 16 is for each student to experience these things through discussions, lab work, group projects, case studies and tear-downs. The stuff at the base of Bloom’s Pyramid (right) which was once the bread & butter of survey-level undergraduate courses, can now be found in TED talks or Wikipedia. No matter, I’d much rather spend our time close to the summit!

Extreme...

Paradoxically, extreme conditions can impose constraints on an engineer that will result in more creative solutions. It’s my goal to push through the everyday and mundane and challenge you to come up with solutions that are outlandish and bold. I’m guided by the principle that every human deserves health, even if they live in war-torn Afghanistan or 16,500 feet above sea level in the Peruvian Andes. These are extreme scenarios--and my goal is to curate as many of these as I can, so we can ideate, prototype and test solutions.

My goal is to run ENGS 16 very agile—perhaps an extreme idea in it’s own right. I firmly believe that the student should be in the drivers seat as much as possible. ENGS 16 will give every student the chance to develop a solution to a real global health challenge in less than 6 weeks!

Empowering...

Individuals living in resource-limited settings deal with diseases that are stigmatizing and poverty promoting. Global health technology can connect, educate, diagnose and monitor individuals. Rapidly deployable microcomputers can allow the end-user to hack their own solution to a health need.

ENGS 16 will also empower students. Fears waste human time, effort, and creativity we need to solve global health challenges. These include fear of the unknown, fear of making mistakes, and fear of losing control. A major goal of ENGS 16 is to employ participatory teaching methods to overcome these fears and enable the student to develop and retain knowledge and skills that can be used to make an impact into the future.

 

Published Papers (17)

Elliott JT et al. (2014) Perfusion CT estimates PS uptake and biodistribution in a rabbit orthotopic pancreatic cancer model: a pilot study Acad Radiol DOI: 10.1016/j.acra.2014.12.014

Venkat Krishnaswamy, Jonathan T. Elliott, David McClatchy III, Richard Barth Jr., Wendy Wells, Brian Pogue, Keith Paulsen. Structured Light Scatteroscopy. JBO Letters 2014 (in press).

Kenneth M. Tichauer, Mamadou Diop, Jonathan T. Elliott, Kimberley S. Samkoe, Tayyaba Hasan, Keith St. Lawrence, Brian W. Pogue. Accounting for pharmacokinetic differences in dual-tracer receptor density imaging. Physics in Medicine and Biology 2014; 59(10):2341-51.

Jonathan T. Elliott, Mamadou Diop, Laura B. Morrison, Christopher D d’Esterre, Ting-Yim Lee, and Keith St. Lawrence. Quantifying cerebral blood flow in an adult pig ischemia model by a depth-resolved dynamic contrast-enhanced optical method. Neuroimage 2014; 94: 303-311. [link]

Nazanin Hamzei, Kimberley S. Samkoe, Jonathan T. Elliott, Jason R. Gunn, Tayyaba Hasan, Brian W. Pogue, Kenneth M. Tichauer. Comparison of kinetic models for dual-tracer receptor concentration imaging in tumors. Austin Journal of Biomedical Engineering 2014; 1(1):9.

Jonathan T. Elliott, Kenneth M. Tichauer, Kimberley S. Samkoe, Jason R. Gunn, Kristian J. Sexton, Brian W. Pogue. Direct characterization of arterial input functions by fluorescence imaging of exposed carotid artery to facilitate kinetic analysis. Molecular Imaging in Biology 2014 [link];

Rohit Arora, Mustafa Ridha, David S. C. Lee, Jonathan T. Elliott, Herschel C. Rosenberg, Mamadou Diop, Ting-Yim Lee, Keith St. Lawrence. Preservatino of the metabolic rate of oxygen in preterm infants during indomethacin therapy for closure of the ductus arteriosus. Pediatric Research 2013;

Keith St. Lawrence, Kyle Verdecchia, Jonathan T. Elliott, Kenneth M. Tichauer, Mamadou Diop, Lisa Hoffman, Ting-Yim Lee. Kinetic model optimization for characterizing tumour physiology by dynamic contrast-enhanced near-infrared spectroscopy. Physics in Medicine and Biology 2013; 58(5):1591.

Jonathan T. Elliott, Daniel Milej, Anna Gerega, Wojciech Weigl, Mamadou Diop, Laura B. Morrison, Ting-Yim Lee, Adam Liebert, and Keith St. Lawrence. Variance of time-of-flight distribution is sensitive to cerebral flow dynamics of indocyanine green as confirmed by comparing scalp and brain measurements in adult pigs. Biomedical Optics Express 2013; 4(2):206.

Jonathan T. Elliott, Eric A. Wright, Kenneth M. Tichauer, Mamadou Diop, Laura B. Morrison, Brian W. Pogue, Ting-Yim Lee, and Keith St. Lawrence. Arterial input function of an optical tracer for dynamic contrast enhanced imaing can be determined from pulse oximetry oxygen saturation measurements. Physics in Medicine and Biology 2012; 57(24):8285-95 [link].

Hadi Zabihi Yeganeh,Vladislav Toronov, Jonathan T. Elliott, Mamadou Diop, Ting-Yim Lee, and Keith St. Lawrence. Broadband continuous-wave technique to measure baseline values and changes in the tissue chromophore concentrations. Biomedical Optics Express2012; 3(11):2761-2770

Jonathan T. Elliott, Mamadou Diop, Ting-Yim Lee, and Keith St. Lawrence. A model-independent dynamic constraint to improve the optical reconstruction of regional kinetic parameters. Optics Letters2012; 37 (13): 2571-2573 [link]

Joel A. Cooper, Kenneth M. Tichauer, Melfort Boulton, Jonathan T. Elliott, Mamadou Diop, Miguel Arango, Ting-Yim Lee, and Keith St. Lawrence Continuous Monitoring of Absolute Cerebral Blood Flow by Near-Infrared Spectroscopy During Global and Focal Temporary Vessel Occlusion. Journal of Applied Physiology 2011; 110: 1691-1698.

Kenneth M. Tichauer, Mark Migueis, Frederic Leblond, Jonathan T. Elliott Mamadou Diop, Keith St. Lawrence, and Ting-Yim Lee. Depth resolution and multiexponential lifetime analyses of reflectance-based time-domain fluorescence data. Applied Optics 2011; 50(21): 3962-72.

Mamadou Diop, Kenneth Tichauer, Jonathan T. Elliott, Mark Migueis, Ting-Yim Lee and Keith St. Lawrence. A comparison of time-resolved and continuous-wave near-infrared techniques measuring cerebral blood flow in piglets. Journal of Biomedical Optics 2010; 15(5), 057004.

Jonathan T. Elliott, Mamadou Diop, Kenneth M. Tichauer, Ting-Yim Lee and Keith St. Lawrence. Quantitative measurement of cerebral blood flow in a juvenile porcine model by depth-resolved near-infrared spectroscopy. Journal of Biomedical Optics 2010; 15(3), 037014.

Kenneth M. Tichauer, Jonathan T. Elliott, Jennifer A. Hadway, David S. Lee, Ting-Yim Lee and Keith St. Lawrence. Using near-infrared spectroscopy to measure the cerebral metabolic rate of oxygen under multiple levels of hypoxia in piglets. Journal of Applied Physiology 2010; 109(3):878-85.

Mamadou Diop, Jonathan T. Elliott, Kenneth M. Tichauer, Ting-Yim Lee, and Keith St. Lawrence. A Broadband Continuous-Wave Multi-Channel NIRS System for Measuring Regional Cerebral Blood Flow in Neonates. Review of Scientific Instruments 2009; 80(5), 054302.

Kenneth M. Tichauer, Jonathan T. Elliott, Jennifer A. Hadway, Ting-Yim Lee, and Keith St. Lawrence. Cerebral metabolic rate of oxygen and amplitude-integrated electroencephalography during early reperfusion after hypoxia-ischemia in piglets. Journal of Applied Physiology 2009; 106(5):1506-12.

Book Chapters (1)

Mamadou Diop, Jonathan T. Elliott, T-Y Lee and KS St Lawrence. Towards non-invasive bedside monitoring of cerebral blood flow and oxygen metabolism in brain-injured patients with near-infrared spectroscopy. In A Agrawal (Ed.), Brain Injury: Book 1. Rijeka, Croatia: InTech Publishers; 2011 (in press).

Published Proceedings (4)

Vladislav Toronov, Jonathan T. Elliott, Ting-Yim Lee, Keith St. Lawrence. Depth-resolved quantitative measurement of CBF using broad-band NIRS and a two-layer head model. Proceedings of SPIE2011; 8088, 80881J.

Jonathan T. Elliott, Mamadou Diop, Kenneth M. Tichauer, Ting-Yim Lee, Keith St. Lawrence. Monte Carlo based modeling of indocyanine green bolus tracking in the adult human head.Proceedings of SPIE 2011; 7896.

Jonathan T. Elliott, Kenneth M. Tichauer, Mamadou Diop, Ting-Yim Lee, Keith St. Lawrence. Fast Monte Carlo fitting of two-layered tissue structures for short source-detector distance. Proceedings of SPIE 2011; 7896.

Mamadou Diop, Kenneth M. Tichauer, Jonathan T. Elliott, Mark Migueis, Ting-Yim Lee, Keith St. Lawrence. Time-resolved near-infrared technique for bedside monitoring of absolute cerebral blood flow. Proceedings of SPIE 2010; 7555: 75550Z.

Patents (2)

Venkataramanan Krishnaswamy, Brian W. Pogue, Keith D. Paulsen, Jonathan T. Elliott, David M. McClatchy III. Apparatus and methods for structured light scatteroscopy. US Patent Application No. 61/935,803, February 4, 2014.

Jonathan T. Elliott, Keith St. Lawrence, Ting-Yim Lee, Mamadou Diop, and Kenneth Tichauer. Kinetic deconvolution optical reconstruction method. U.S. Patent Application No.  61/606346, March 2, 2012 [link].

Conference Abstracts (23)

Jonathan T. Elliott, Mamadou Diop, Ting-Yim Lee, Keith St. Lawrence. Comparison of CT perfusion and bedside optical measurements of cerebral blood flow in an adult pig model of ischemia. World Stroke Congress, Brasilia, Brazil, October 2012 (submitted April, 2012).

Jonathan T. Elliott, Kenneth M. Tichauer, Robert W. Holt, Stephen C. Kanick, Keith St. Lawrence, Brian W. Pogue, Frederic Leblond. Comparison of Monte Carlo and diffusion approximation light modeling in small animal fluorescence tomography. Biomedical Optics and 3-D Imaging: OSA Optics and Photonics Congress, Miami, Florida, April 2012.

Jonathan T. Elliott, Mamadou Diop, Ting-Yim Lee, Keith St. Lawrence. Cerebral blood flow quantification during ischemia using a multi-distance moments-based time-resolved technique. Biomedical Optics and 3-D Imaging: OSA Optics and Photonics Congress, Miami, Florida, April 2012.

Hadi Zabihi Yeganeh, Vladislav Toronov, Jonathan T. Elliott, Mamadou Diop, Ting-Yim Lee, and Keith St. Lawrence. Quantitative measurement of Cerebral Blood Flow, using broad band, continuous wave near infrared spectroscopy. Biomedical Optics and 3-D Imaging: OSA Optics and Photonics Congress, Miami, Florida, April 2012.

Jonathan T. Elliott, Christopher J. Chin, Jason A. Franklin. Using computational fluid dynamic modeling to predict flow disturbance and thrombosis within arterial microvascular anastomosis. International Conference on Head and Neck Cancer, Toronto, ON, July 21-25, 2012.

Christopher J. Chin, Jonathan T. Elliott, Jason A. Franklin. A computational fluid dynamic model of the microvascular venous anastomotic options in head and neck reconstruction. International Conference on Head and Neck Cancer, Toronto, ON, July 21-25, 2012

Jonathan T. Elliott, Mamadou Diop, Ting-Yim Lee, Keith St. Lawrence. Measuring hemodynamic parameters during ischemia with an optical indicator-dilution technique (Oral presentation). London Health Research Day, London, Ontario, March 2012.

Christopher J. Chin, Jonathan T. Elliott, Jason H. Franklin. Using CFD modeling to predict disturbance and thrombosis within microvascular anastomosis. London Health Research Day, London, Ontario, March 2012.

Vladislav Toronov, Jonathan T. Elliott, Ting-Yim Lee, and Keith St. Lawrence. Depth-resolved quantitative measurement of cerebral blood flow using broad-band near infrared spectroscopy and a two-layer head model. SPIE/OSA European Conferences on Biomedical Optics, Munich, Germany, May 2011.

Jonathan T. Elliott, Mamadou Diop, Laura B. Morrison, Ting-Yim Lee, and Keith St. Lawrence. Quantitative measurement of cerebral blood flow in an adult porcine model of ischemia using a time-resolved near-infrared technique. Brain 2011 (25thInternational Symposium on Cerebral Blood Flow, Metabolism, and Function) Barcelona, Spain, May 2011.

Jonathan T. Elliott, Mamadou Diop, Ting-Yim Lee, Keith St. Lawrence. Theoretical time-resolved near-infrared measurements of indicator-dilution in the human head using tracer kinetic modeling and serial Monte Carlo simulations. Brain 2011 (25th International Symposium on Cerebral Blood Flow, Metabolism, and Function) Barcelona, Spain, May 2011.

Jonathan T. Elliott, Mamadou Diop, Ting-Yim Lee, Keith St. Lawrence. Non-invasive bedside optical measurement of cerebral blood flow (Oral presentation). Lawson Research Day, London, Ontario, Mar. 2011.

Mustafa Ridha, Jonathan T. Elliott, Rohit Arora, Ting-Yim Lee, David S. Lee, Keith St. Lawrence. Using near-infrared spectroscopy to monitor cerebral hemodynamics and metabolism in very low birth weight neonates treated for patent ductus arteriosus. Hot Topics in Neonatology, Washington, D.C. Dec 5-7, 2010.

Jonathan T. Elliott, Mamadou Diop, Kenneth M. Tichauer, Ting-Yim Lee, Keith St. Lawrence. Monte Carlo based modeling of indocyanine green bolus tracking in the adult human head (Oral Presentation). BiOS conference, SPIE, San Francisco, CA, Jan. 2011.

Jonathan T. Elliott, Kenneth M. Tichauer, Mamadou Diop and Keith St. Lawrence. Fast Monte Carlo fitting of two-layered tissue structures for short source-detector distances. BiOS conference, SPIE, San Francisco, CA, January 2011.

Jonathan T. Elliott, Mamadou Diop, Kenneth Tichauer, Ting-Yim Lee, and Keith St. Lawrence. Quantification of cerebral blood flow in the adult using near-infrared spectroscopy assisted by subject-individualized Monte Carlo modeling (Oral Presentation).Biomedical Optics and 3-D Imaging: OSA Optics and Photonics Congress, Miami Beach, Florida, March 2010.

Jonathan T. Elliott, Kenneth Tichauer, Mamadou Diop, and Keith St. Lawrence. Fast Monte Carlo simulations for quantifying optical properties from short source-detector separation geometries. Biomedical Optics and 3-D Imaging: OSA Optics and Photonics Congress, Miami Beach, FL, March 2010.

Mamadou Diop, Kenneth M. Tichauer, Jonathan T. Elliott, Ting-Yim Lee, and Keith St. Lawrence. Time-resolved near-infrared technique for bedside monitoring of absolute blood flow (Oral Presentation). BiOS conference, SPIE, San Francisco, California, January 2010.

Jonathan T. Elliott, Mamadou Diop, Kenneth M. Tichauer, Ting-Yim Lee, Keith St. Lawrence. Measurement of Cerebral Blood Flow in the Adult Pig by Depth-Resolved Broadband Near-Infrared Spectroscopy. Brain ‘09 (24rd International Symposium on Cerebral Blood Flow, Metabolism, and Function) Chicago, Illinois, July 2009.

Kenneth M. Tichauer, Jonathan T. Elliott, Jennifer A. Hadway, Ting-Yim Lee, Keith St. Lawrence. Real-Time Tracking of Cerebral Blood Flow during Arterial Occlusion by Near-Infrared Spectroscopy.  Brain ’09 (24rd International Symposium on Cerebral Blood Flow, Metabolism, and Function) Chicago, Illinois, July 2009.

Kenneth M. Tichauer, Jonathan T. Elliott, Jennifer A. Hadway, Ting-Yim Lee, Keith St. Lawrence. Comparison of Independent Techniques for Measuring Cerebral Venous Oxygenation in Neonates. Oral Presentation. Brain ’09 (24rd International Symposium on Cerebral Blood Flow, Metabolism, and Function) Chicago, Illinois, July 2009.

Mamadou Diop, Jonathan T. Elliott, Kenneth M. Tichauer, Ting-Yim Lee, Keith St. Lawrence. A Broadband Multi-Channel NIRS System for Measuring Focal Ischemic Brain Injury in Newborns. Brain ’09 (24rd International Symposium on Cerebral Blood Flow, Metabolism, and Function) Chicago, Illinois, July 2009.

Mamadou Diop, Jonathan T. Elliott, Kenneth M. Tichauer, Lynn Keenliside, Ting-Yim Lee, Keith St. Lawrence. Development of a broadband multi-channels NIRS system for measuring regional cerebral blood flow. OSA (Optical Society of America) Biomedical Optics Topical Meetings, St. Petersburg, Florida, March 2008.