BIOGRAPHY

With the family at Dartmouth Skiway, Lyme, NH

I’m a Research Associate at Dartmouth College in New Hampshire working in the Optics in Medicine Group as a CIHR Fellow in Cancer Research. My research strives to apply biotechnology--including imaging and sensing--to improve cancer surgery. Right now, I work mostly in the fluorescence-guided surgery space, where I develop smart probes that target tumors based on molecular expression. I am passionate about human-centered design: how can I provide high-level information to surgeons DURING complicated cancer surgery, in a way that is helpful and natural. This problem intersects medical imaging, tracer kinetics, computer vision, optical engineering, physiology, oncology, molecular biology, to name a few...which is perfect, since I love to learn new things every day!.

When I’m not playing around with lasers, I am almost certainly hiking, skiing, or kicking around a ball with my family. I am fortunate to have the support of my wonderful wife Laura, the “high-fives” of our son, Yianni, and smiles of our daughter, Ruby, which encourage me each day.

Thanks for visiting my website, where you’ll find some information on my current projects. Some of my recent conference talks and posters can be downloaded from the “resources” page. When all else fails, feel free to contact me if you have any questions!

 

 

biography
research
teaching
pubs
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research

Fluorescence-guided surgery to improve glioma resection

Source: Center for Surgical Innovation, DHMC, Lebanon, NH

With surgery, Glioblastoma multiforme (GBM) has a mean survival of 15 months, but a high extent of tumor resection is associated with a longer survival; although survival past 5 years is extremely rare, all documented long-term survivors had very high extent of tumor resection. A prinicple research goal of mine is to develop image-guided (incuding fluorescence-guided and multi-modal guide) surgery methods to improve tumor resection during open craniotomy--the principle type of surgery used to treat GBM.

A unique area of research I am actively pursuing is the use of tracer kinetics, coupled with an antibody fragment targeted fluorescent dye being produced by a cGMP pipeline as part of a partnership between Dartmouth, Affibody and LI-COR Biosciences. By developing a fluorescence tracer that attaches to receptors overexpressed in most GBM tumor cells, and then leveraging existing model frameworks developed for PET, CT, and MRI dynamic imaging, a quantitative map of tumor burden based on molecular expression is presented to the surgeon.

As a strong believer in human-centered design principles, the focus of my research extends past the technological or biological, but also includes a focus on designing the technology to be compatible with the current surgical workflow. I utilize current imaging protocols, standard equipment such as the Carl Ziess surgical microscope, and most recently, am exploring the use of intraoperative CT and MRI which is possible through the Center for Surgical Innovation and Dartmouth-Hitchcock Medical Center.

Photodynamic therapy in pancreatic cancer: DCE CT imaging, kinetic modeling and dosimetery

Photodynamic therapy (PDT) is an emerging treatment option and is being investigated in several clinical applications, including skin and pancreatic cancer. In PDT, a photosensitizer (PS) drug is injected into the patent, and is taken up, preferentially, by malignant tissue due to the enhanced uptake and permeability effect. At some time following injection, near-infrared light is delivered to the tumor, causing the PS to oxidize and kill tumor cells and vessels. Current standard-of-practice is to deliver the light at some standard time following injection, for all patients. However, tumors are highly heterogeneous, and therefore exhibit different blood flow, permeability and washout properties. The purpose of this project is to determine the degree to which individualized light delivery timing based on CT perfusion kinetic parameters enhanced local tumor control.

KS Samkoe, JT Elliott, EE Stewart, JR Gunn, KM Tichauer, KL Moddie, S Kane, PJ Hoopes, T-Y Lee, SP Pereira, T Hasan, BW Pogue. Perfusion CT as a surrogate for verteporfin PDT doimetry in pancreatic cancer: validation in rabbit tumor model studies. SPIE BiOS Paper 8931-36; Feb. 2014.

Light-based technology for neurointensive care monitoring

Acquired brain injury (ABI)—including traumatic brain injury, stroke, and subarachnoid hemorrhage—represents the largest source of death and disability in children and young adults. Recovery from ABI is often confounded by complications that cause a reduction in blood flow to the brain. The goal of this project is to develop an optical instrument that can quantify cerebral blood flow at the bedside, and non-invasively.

JT Elliott, M Diop, LB Morrison, T-Y Lee, K St. Lawrence. Reconstruction of cerebral hemodynamics with dynamic contrast enhanced time-resolved near-infrared measurement of before and during ischemia. SPIE BiOS 85780A-7; 2013.

JT Elliott, D Milej, A Gerega, W Weigl, M Diop, LB Morrison, T-Y Lee, A Liebert, K St. Lawrence. Variance of time-of-flight distribution is sensitive to cerebral flow dynamics of indocyanine green as confirmed by comparing scalp and brain measurements in adult pigs. Biomed Opt Expr 4(1); 2012.

Optical imaging of cancer to characterize angiogenesis and molecular binding

The technologies developed for the GBM project are generalizable to other forms of cancer, other molecular targets, and preclinical as well as clinical applications. Kinetic modeling using a passive tracer can be used to characterize the leakiness of tissue—a hallmark of angiogenesis that is indicative of aggressive neoplasms. Targeted tracers can quantify the molecular binding potential of highly specific surface receptors like epidermal growth factor. The goal of this project is to develop analytical tools to accurately determine these important parameters for preclinical and drug development applications.

JT Elliott, E Wright, K Tichauer, M Diop, LB Morrison, BW Pogue, T-Y Lee, K St. Lawrence. Arterial input function of an optical tracer can be determined from pulse oximetry oxygen saturation measurements.Phys Med Biol 57(14); 2012.

K St Lawrence, K Verdecchia, J Elliott, K Tichauer, M Diop, L Hoffman, TY Lee. Kinetic model optimization for characterizing tumour physiology by dynamic contrast-enhanced near-infrared spectroscopy. Phys Med Biol 58 (5), 1591

Light-based technology for neonatal intensive care monitoring

About 10-15% of infants are admitted to the neonatal intensive care unit, for a variety of reasons. Patent ductus arteriosis is a heart condition common in premature infants, which can be treated with NSAIDs but may require surgical ligation. Other conditions include birth asphyxia and cerebral palsy. The goal of this project is to use near-infrared spectroscopy to monitor blood flow to the brain, to assess disruptions caused by the condition and predict severity of the injury.

R Arora, M Ridha, DSC Lee, J Elliott, HC Rosenberg, M Diop, TY Lee, K St. Lawrence. Preservation of the metabolic rate of oxygen in preterm infants during indomethacin therapy for closure of the ductus arteriosus Pediatr Res. 2013.

M Diop, KM Tichauer, JT Elliott, M Migueis, TY Lee, KS Lawrence. Comparison of time-resolved and continuous-wave near-infrared techniques for measuring cerebral blood flow in piglets. J Biomed Opt 15(5); 2010.

Head and neck cancer research

In head and neck cancer, tumor resection typically results in a large defect that must be repaired with reconstructive surgery. With the advent of free tissue transfer, the success rates of reconstruction is high. However, serious complications can still occur when blood clots form and block supply to the flap. The goal of this project is to develop a computational fluid dynamic model to predict which flap / vessel combinations will have the lowest risk of thrombosis.

JT Elliott, CJ Chin, JA Franklin. Using computational fluid dynamic modeling to predict flow disturbance and thrombosis within arterial microvascular anastomosis. International Conference on Head and Neck Cancer; 2012.

CJ Chin, JT Elliott, JA Franklin. A computational fluid dynamic model of the microvascular venous anastomotic options in head and neck reconstruction. International Conference on Head and Neck Cancer; 2012.

Optical reconstruction and quantification methods

Optical reconstruction involves collecting light with multiple detectors and then combining the information to form an image (2D or 3D), similar to computed tomography. However, unlike CT, optical reconstruction is a mathematically unstable process. The goal of this project is to develop novel ways to constrain the inverse problem, including the kinetic deconvolution optical reconstruction method.

JT Elliott, M Diop, TY Lee, K St. Lawrence. Model-independent dynamic constraint to improve the optical reconstruction of regional kinetic parameters. Opt Lett 37 (13); 2012.

JT Elliott, KM Tichauer, R Holt, SC Kanick, K St Lawrence, B Pogue, F Leblond. Comparison of Monte Carlo and Diffusion Approximation Light Modeling in Small Animal Fluorescence TomographyBiomedical Optics, OSA Technical Digest, BTu3A.63

JT Elliott, KM Tichauer, M Diop, KS Lawrence. Fast Monte Carlo fitting of two-layered tissue structures for short source-detector distances. SPIE BiOS, 789611-8; 2011.

 

teaching

I happen to work at one of the top-ranked schools in the US for undergraduate teaching. There are a lot of exciting things happening at Dartmouth, and Thayer is leading-edge in terms of concepts such as experiential learning, flipping the classroom, and project-based (and not departmentally siloed) classrooms.

Currently, I teach two courses, both in collaboration with other researchers and professors:

Biomedical Engineering for Global Health (ENGS 16)

Source: AFP/Getty Images

This new course is coming to Thayer in the Winter '15 term. The idea for this course came from a workshop I attended at MIT entitled "Optics in the Developing World", and after discussions with several colleagues, we decided to propose this new course to fill the need for an biomedical engineering course that looks at how to design medical technologies for the majority of the world's population, who don't have access to advanced medical care. We've seized on the opportunity to leverage several of the unique departments here at Dartmouth, as well as the experiential-learning approach of Thayer, to design a very interactive, fulfilling and inspiring student experience. The course handbook description of the course reads as follows:

The past 20 years have seen an incredible amount of high-tech medical advances, but to what degree have these impacted the health of those living in the developing world? The potential for years of life gained through biomedical technology is tremendous in some of the world’s poorest regions, but appropriate design requires an understanding of the clinical, political, and cultural landscape, and a clean-slate approach to developing low-cost, effective tech. This course offers an exciting opportunity to understand how to design solutions for the most important health challenges of the developing world. Learning goals will be achieved through hands-on experience, including: a laboratory component where we deconstruct, design, and build a low-cost medical device, case study discussions on successful global health innovations, and several “teardowns” of common medical devices. Lecturers from Thayer School, Tuck School of BusinessThe Dartmouth Center for Health Care Delivery Science, and Geisel School of Medicine will cover complimentary topics in clinical medicine, healthcare delivery, innovation, and medical imaging. A final project will bring everything together by addressing a real health problem with a prototype of a low-cost tech solution. Enrollment is limited to 40 students.

Quantitative Human Physiology (ENGS 166)

Introduction to human physiology using the quantitative methods of engineering and physical science. Topical coverage includes cellular membrane ion transport, Hodgkin-Huxley models and action potentials, musculoskeletal system, cardiovascular physiology, respiratory physiology, and nervous system physiology. Laboratory exercises and a final project delve into the measurement of human physiology, data analysis, and model testing.

 

Published Papers (17)

Venkat Krishnaswamy, Jonathan T. Elliott, David McClatchy III, Richard Barth Jr., Wendy Wells, Brian Pogue, Keith Paulsen. Structured Light Scatteroscopy. JBO Letters 2014 (in press).

Kenneth M. Tichauer, Mamadou Diop, Jonathan T. Elliott, Kimberley S. Samkoe, Tayyaba Hasan, Keith St. Lawrence, Brian W. Pogue. Accounting for pharmacokinetic differences in dual-tracer receptor density imaging. Physics in Medicine and Biology 2014; 59(10):2341-51.

Jonathan T. Elliott, Mamadou Diop, Laura B. Morrison, Christopher D d’Esterre, Ting-Yim Lee, and Keith St. Lawrence. Quantifying cerebral blood flow in an adult pig ischemia model by a depth-resolved dynamic contrast-enhanced optical method. Neuroimage 2014; 94: 303-311. [link]

Nazanin Hamzei, Kimberley S. Samkoe, Jonathan T. Elliott, Jason R. Gunn, Tayyaba Hasan, Brian W. Pogue, Kenneth M. Tichauer. Comparison of kinetic models for dual-tracer receptor concentration imaging in tumors. Austin Journal of Biomedical Engineering 2014; 1(1):9.

Jonathan T. Elliott, Kenneth M. Tichauer, Kimberley S. Samkoe, Jason R. Gunn, Kristian J. Sexton, Brian W. Pogue. Direct characterization of arterial input functions by fluorescence imaging of exposed carotid artery to facilitate kinetic analysis. Molecular Imaging in Biology 2014 [link];

Rohit Arora, Mustafa Ridha, David S. C. Lee, Jonathan T. Elliott, Herschel C. Rosenberg, Mamadou Diop, Ting-Yim Lee, Keith St. Lawrence. Preservatino of the metabolic rate of oxygen in preterm infants during indomethacin therapy for closure of the ductus arteriosus. Pediatric Research 2013;

Keith St. Lawrence, Kyle Verdecchia, Jonathan T. Elliott, Kenneth M. Tichauer, Mamadou Diop, Lisa Hoffman, Ting-Yim Lee. Kinetic model optimization for characterizing tumour physiology by dynamic contrast-enhanced near-infrared spectroscopy. Physics in Medicine and Biology 2013; 58(5):1591.

Jonathan T. Elliott, Daniel Milej, Anna Gerega, Wojciech Weigl, Mamadou Diop, Laura B. Morrison, Ting-Yim Lee, Adam Liebert, and Keith St. Lawrence. Variance of time-of-flight distribution is sensitive to cerebral flow dynamics of indocyanine green as confirmed by comparing scalp and brain measurements in adult pigs. Biomedical Optics Express 2013; 4(2):206.

Jonathan T. Elliott, Eric A. Wright, Kenneth M. Tichauer, Mamadou Diop, Laura B. Morrison, Brian W. Pogue, Ting-Yim Lee, and Keith St. Lawrence. Arterial input function of an optical tracer for dynamic contrast enhanced imaing can be determined from pulse oximetry oxygen saturation measurements. Physics in Medicine and Biology 2012; 57(24):8285-95 [link].

Hadi Zabihi Yeganeh,Vladislav Toronov, Jonathan T. Elliott, Mamadou Diop, Ting-Yim Lee, and Keith St. Lawrence. Broadband continuous-wave technique to measure baseline values and changes in the tissue chromophore concentrations. Biomedical Optics Express2012; 3(11):2761-2770

Jonathan T. Elliott, Mamadou Diop, Ting-Yim Lee, and Keith St. Lawrence. A model-independent dynamic constraint to improve the optical reconstruction of regional kinetic parameters. Optics Letters2012; 37 (13): 2571-2573 [link]

Joel A. Cooper, Kenneth M. Tichauer, Melfort Boulton, Jonathan T. Elliott, Mamadou Diop, Miguel Arango, Ting-Yim Lee, and Keith St. Lawrence Continuous Monitoring of Absolute Cerebral Blood Flow by Near-Infrared Spectroscopy During Global and Focal Temporary Vessel Occlusion. Journal of Applied Physiology 2011; 110: 1691-1698.

Kenneth M. Tichauer, Mark Migueis, Frederic Leblond, Jonathan T. Elliott Mamadou Diop, Keith St. Lawrence, and Ting-Yim Lee. Depth resolution and multiexponential lifetime analyses of reflectance-based time-domain fluorescence data. Applied Optics 2011; 50(21): 3962-72.

Mamadou Diop, Kenneth Tichauer, Jonathan T. Elliott, Mark Migueis, Ting-Yim Lee and Keith St. Lawrence. A comparison of time-resolved and continuous-wave near-infrared techniques measuring cerebral blood flow in piglets. Journal of Biomedical Optics 2010; 15(5), 057004.

Jonathan T. Elliott, Mamadou Diop, Kenneth M. Tichauer, Ting-Yim Lee and Keith St. Lawrence. Quantitative measurement of cerebral blood flow in a juvenile porcine model by depth-resolved near-infrared spectroscopy. Journal of Biomedical Optics 2010; 15(3), 037014.

Kenneth M. Tichauer, Jonathan T. Elliott, Jennifer A. Hadway, David S. Lee, Ting-Yim Lee and Keith St. Lawrence. Using near-infrared spectroscopy to measure the cerebral metabolic rate of oxygen under multiple levels of hypoxia in piglets. Journal of Applied Physiology 2010; 109(3):878-85.

Mamadou Diop, Jonathan T. Elliott, Kenneth M. Tichauer, Ting-Yim Lee, and Keith St. Lawrence. A Broadband Continuous-Wave Multi-Channel NIRS System for Measuring Regional Cerebral Blood Flow in Neonates. Review of Scientific Instruments 2009; 80(5), 054302.

Kenneth M. Tichauer, Jonathan T. Elliott, Jennifer A. Hadway, Ting-Yim Lee, and Keith St. Lawrence. Cerebral metabolic rate of oxygen and amplitude-integrated electroencephalography during early reperfusion after hypoxia-ischemia in piglets. Journal of Applied Physiology 2009; 106(5):1506-12.

Book Chapters (1)

Mamadou Diop, Jonathan T. Elliott, T-Y Lee and KS St Lawrence. Towards non-invasive bedside monitoring of cerebral blood flow and oxygen metabolism in brain-injured patients with near-infrared spectroscopy. In A Agrawal (Ed.), Brain Injury: Book 1. Rijeka, Croatia: InTech Publishers; 2011 (in press).

Published Proceedings (4)

Vladislav Toronov, Jonathan T. Elliott, Ting-Yim Lee, Keith St. Lawrence. Depth-resolved quantitative measurement of CBF using broad-band NIRS and a two-layer head model. Proceedings of SPIE2011; 8088, 80881J.

Jonathan T. Elliott, Mamadou Diop, Kenneth M. Tichauer, Ting-Yim Lee, Keith St. Lawrence. Monte Carlo based modeling of indocyanine green bolus tracking in the adult human head.Proceedings of SPIE 2011; 7896.

Jonathan T. Elliott, Kenneth M. Tichauer, Mamadou Diop, Ting-Yim Lee, Keith St. Lawrence. Fast Monte Carlo fitting of two-layered tissue structures for short source-detector distance. Proceedings of SPIE 2011; 7896.

Mamadou Diop, Kenneth M. Tichauer, Jonathan T. Elliott, Mark Migueis, Ting-Yim Lee, Keith St. Lawrence. Time-resolved near-infrared technique for bedside monitoring of absolute cerebral blood flow. Proceedings of SPIE 2010; 7555: 75550Z.

Patents (2)

Venkataramanan Krishnaswamy, Brian W. Pogue, Keith D. Paulsen, Jonathan T. Elliott, David M. McClatchy III. Apparatus and methods for structured light scatteroscopy. US Patent Application No. 61/935,803, February 4, 2014.

Jonathan T. Elliott, Keith St. Lawrence, Ting-Yim Lee, Mamadou Diop, and Kenneth Tichauer. Kinetic deconvolution optical reconstruction method. U.S. Patent Application No.  61/606346, March 2, 2012 [link].

Conference Abstracts (23)

Jonathan T. Elliott, Mamadou Diop, Ting-Yim Lee, Keith St. Lawrence. Comparison of CT perfusion and bedside optical measurements of cerebral blood flow in an adult pig model of ischemia. World Stroke Congress, Brasilia, Brazil, October 2012 (submitted April, 2012).

Jonathan T. Elliott, Kenneth M. Tichauer, Robert W. Holt, Stephen C. Kanick, Keith St. Lawrence, Brian W. Pogue, Frederic Leblond. Comparison of Monte Carlo and diffusion approximation light modeling in small animal fluorescence tomography. Biomedical Optics and 3-D Imaging: OSA Optics and Photonics Congress, Miami, Florida, April 2012.

Jonathan T. Elliott, Mamadou Diop, Ting-Yim Lee, Keith St. Lawrence. Cerebral blood flow quantification during ischemia using a multi-distance moments-based time-resolved technique. Biomedical Optics and 3-D Imaging: OSA Optics and Photonics Congress, Miami, Florida, April 2012.

Hadi Zabihi Yeganeh, Vladislav Toronov, Jonathan T. Elliott, Mamadou Diop, Ting-Yim Lee, and Keith St. Lawrence. Quantitative measurement of Cerebral Blood Flow, using broad band, continuous wave near infrared spectroscopy. Biomedical Optics and 3-D Imaging: OSA Optics and Photonics Congress, Miami, Florida, April 2012.

Jonathan T. Elliott, Christopher J. Chin, Jason A. Franklin. Using computational fluid dynamic modeling to predict flow disturbance and thrombosis within arterial microvascular anastomosis. International Conference on Head and Neck Cancer, Toronto, ON, July 21-25, 2012.

Christopher J. Chin, Jonathan T. Elliott, Jason A. Franklin. A computational fluid dynamic model of the microvascular venous anastomotic options in head and neck reconstruction. International Conference on Head and Neck Cancer, Toronto, ON, July 21-25, 2012

Jonathan T. Elliott, Mamadou Diop, Ting-Yim Lee, Keith St. Lawrence. Measuring hemodynamic parameters during ischemia with an optical indicator-dilution technique (Oral presentation). London Health Research Day, London, Ontario, March 2012.

Christopher J. Chin, Jonathan T. Elliott, Jason H. Franklin. Using CFD modeling to predict disturbance and thrombosis within microvascular anastomosis. London Health Research Day, London, Ontario, March 2012.

Vladislav Toronov, Jonathan T. Elliott, Ting-Yim Lee, and Keith St. Lawrence. Depth-resolved quantitative measurement of cerebral blood flow using broad-band near infrared spectroscopy and a two-layer head model. SPIE/OSA European Conferences on Biomedical Optics, Munich, Germany, May 2011.

Jonathan T. Elliott, Mamadou Diop, Laura B. Morrison, Ting-Yim Lee, and Keith St. Lawrence. Quantitative measurement of cerebral blood flow in an adult porcine model of ischemia using a time-resolved near-infrared technique. Brain 2011 (25thInternational Symposium on Cerebral Blood Flow, Metabolism, and Function) Barcelona, Spain, May 2011.

Jonathan T. Elliott, Mamadou Diop, Ting-Yim Lee, Keith St. Lawrence. Theoretical time-resolved near-infrared measurements of indicator-dilution in the human head using tracer kinetic modeling and serial Monte Carlo simulations. Brain 2011 (25th International Symposium on Cerebral Blood Flow, Metabolism, and Function) Barcelona, Spain, May 2011.

Jonathan T. Elliott, Mamadou Diop, Ting-Yim Lee, Keith St. Lawrence. Non-invasive bedside optical measurement of cerebral blood flow (Oral presentation). Lawson Research Day, London, Ontario, Mar. 2011.

Mustafa Ridha, Jonathan T. Elliott, Rohit Arora, Ting-Yim Lee, David S. Lee, Keith St. Lawrence. Using near-infrared spectroscopy to monitor cerebral hemodynamics and metabolism in very low birth weight neonates treated for patent ductus arteriosus. Hot Topics in Neonatology, Washington, D.C. Dec 5-7, 2010.

Jonathan T. Elliott, Mamadou Diop, Kenneth M. Tichauer, Ting-Yim Lee, Keith St. Lawrence. Monte Carlo based modeling of indocyanine green bolus tracking in the adult human head (Oral Presentation). BiOS conference, SPIE, San Francisco, CA, Jan. 2011.

Jonathan T. Elliott, Kenneth M. Tichauer, Mamadou Diop and Keith St. Lawrence. Fast Monte Carlo fitting of two-layered tissue structures for short source-detector distances. BiOS conference, SPIE, San Francisco, CA, January 2011.

Jonathan T. Elliott, Mamadou Diop, Kenneth Tichauer, Ting-Yim Lee, and Keith St. Lawrence. Quantification of cerebral blood flow in the adult using near-infrared spectroscopy assisted by subject-individualized Monte Carlo modeling (Oral Presentation).Biomedical Optics and 3-D Imaging: OSA Optics and Photonics Congress, Miami Beach, Florida, March 2010.

Jonathan T. Elliott, Kenneth Tichauer, Mamadou Diop, and Keith St. Lawrence. Fast Monte Carlo simulations for quantifying optical properties from short source-detector separation geometries. Biomedical Optics and 3-D Imaging: OSA Optics and Photonics Congress, Miami Beach, FL, March 2010.

Mamadou Diop, Kenneth M. Tichauer, Jonathan T. Elliott, Ting-Yim Lee, and Keith St. Lawrence. Time-resolved near-infrared technique for bedside monitoring of absolute blood flow (Oral Presentation). BiOS conference, SPIE, San Francisco, California, January 2010.

Jonathan T. Elliott, Mamadou Diop, Kenneth M. Tichauer, Ting-Yim Lee, Keith St. Lawrence. Measurement of Cerebral Blood Flow in the Adult Pig by Depth-Resolved Broadband Near-Infrared Spectroscopy. Brain ‘09 (24rd International Symposium on Cerebral Blood Flow, Metabolism, and Function) Chicago, Illinois, July 2009.

Kenneth M. Tichauer, Jonathan T. Elliott, Jennifer A. Hadway, Ting-Yim Lee, Keith St. Lawrence. Real-Time Tracking of Cerebral Blood Flow during Arterial Occlusion by Near-Infrared Spectroscopy.  Brain ’09 (24rd International Symposium on Cerebral Blood Flow, Metabolism, and Function) Chicago, Illinois, July 2009.

Kenneth M. Tichauer, Jonathan T. Elliott, Jennifer A. Hadway, Ting-Yim Lee, Keith St. Lawrence. Comparison of Independent Techniques for Measuring Cerebral Venous Oxygenation in Neonates. Oral Presentation. Brain ’09 (24rd International Symposium on Cerebral Blood Flow, Metabolism, and Function) Chicago, Illinois, July 2009.

Mamadou Diop, Jonathan T. Elliott, Kenneth M. Tichauer, Ting-Yim Lee, Keith St. Lawrence. A Broadband Multi-Channel NIRS System for Measuring Focal Ischemic Brain Injury in Newborns. Brain ’09 (24rd International Symposium on Cerebral Blood Flow, Metabolism, and Function) Chicago, Illinois, July 2009.

Mamadou Diop, Jonathan T. Elliott, Kenneth M. Tichauer, Lynn Keenliside, Ting-Yim Lee, Keith St. Lawrence. Development of a broadband multi-channels NIRS system for measuring regional cerebral blood flow. OSA (Optical Society of America) Biomedical Optics Topical Meetings, St. Petersburg, Florida, March 2008.

 

cv

Education

Ph.D., Medical Biophysics, University of Western Ontario (2013)
Thesis Committee: Keith St. Lawrence (advisor), Ting-Yim Lee, Vladislav Toronov
“On the development of a dynamic contrast-enhanced near-infrared technique to measure cerebral blood flow in the neurocritical care unit”

B.M.Sc., (Honours) Medical Science, University of Western Ontario (2008)
Double Major in Physiology and Medical Biophysics

Awards

2013-2015  Canadian Institutes of Health Research Postdoctoral Fellowship

2012  Alfred Jay Award for Innovation and Entrepreneurship
2010-2011  SPIE Scholarship in Optical Science and Engineering
2012  Optical Society of America 2nd Prize

2011-2013  Ontario Graduate Scholarship
2010-2011  Ontario Graduate Scholarship in Science and Technology
2008-2013  Western Graduate Research Scholarship

Invited Presentations

Shining a light on the brain (Retiring with Strong Minds – Outreach Project, Western University, London, ON; June 7, 2013)

Using CFD modeling to predict flow disturbance and thrombosis (Department of Otolaryngology, Western University, London, ON; May 9, 2012)

Monte Carlo Simulations: A random walk from blood flow measurements to fluorescence molecular tomography (Thayer School of Engineering, Dartmouth College, Hanover, NH; Dec. 2, 2011)

Introduction to Monte Carlo in optics – Lecture for MBP 9645a (Department of Medical Biophysics, Western University, London, ON; Nov. 14, 2011)

Features in Popular Press

Simple oximeter enables tracer kinetics in MedicalPhysicsWeb (Jan. 14, 2013)

Evaluation of Articles for Scientific Journals

Biomedical Optics Express
Journal of Biomedical Optics
Applied Optics
Physiological measurements
Neurological Research
Optics Letters

Professional Activities

Member of Optical Society of America
Member of American Physical Society
Member of Canadian Physical Society
Member of the Society of Photo-Optical Instrumentation Engineers
Member of the International Society of Cerebral Blood Flow and Metabolism

 

[Last Updated: 2014-06-23]